https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Does postoperative inflammation or sepsis generate neutrophil extracellular traps that influence colorectal cancer progression? A systematic review https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45013 Thu 27 Oct 2022 17:46:24 AEDT ]]> The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37622 NTR and the proneurotrophin co-receptor sortilin, remains unclear. In the present study, analysis of these proteins was conducted by immunohistochemistry and digital quantification in a series of 204 lung cancers of different histological subtypes versus 121 normal lung tissues. TrkA immunoreactivity was increased in squamous cell carcinoma compared with benign and other malignant lung cancer histological subtypes (p < 0.0001). NGF and proNGF were also increased in squamous cell carcinoma, as well as in adenocarcinoma (p < 0.0001). In contrast, p75NTR was increased across all lung cancer histological subtypes compared to normal lung (p < 0.0001). Sortilin was higher in adenocarcinoma and small cell carcinoma (p < 0.0001). Nerves in the tumor microenvironment were negative for TrkA, NGF, proNGF, p75NTR and sortilin. In conclusion, these data suggest a preferential therapeutic value of targeting the NGF-TrkA axis in squamous cell carcinomas of the lung.]]> Thu 24 Mar 2022 11:36:54 AEDT ]]> Progression in melanoma is associated with decreased expression of death receptors for tumor necrosis factor–related apoptosis-inducing ligand https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1240 Sat 24 Mar 2018 08:28:31 AEDT ]]> Nerve-cancer cell cross-talk: a novel promoter of tumor progression https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28919 Sat 24 Mar 2018 07:25:58 AEDT ]]>